|
Symbol Name ID |
Il6
interleukin 6 MGI:96559 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Cerebral arteriovenous malformation |
Abnormal cerebral vascular morphology |
Stroke |
Anorexia |
Gliosis |
Cerebellar atrophy |
Neuronal loss in central nervous system |
Ataxia |
Gait ataxia |
Bradykinesia |
Chorea |
Cranial nerve paralysis |
Multifocal epileptiform discharges |
Depression |
Irritability |
Personality changes |
Polydipsia |
Polyphagia |
Hyperactivity |
Memory impairment |
Dementia |
Reduced consciousness |
Hyperreflexia |
Migraine |
Peripheral neuropathy |
Polyneuropathy |
Seizure |
| Disease(s) Associated with IL6 | |||||||||||||||||||||||||||
| arteriovenous malformations of the brain | |||||||||||||||||||||||||||
| Graves' disease | |||||||||||||||||||||||||||
| Huntington's disease | |||||||||||||||||||||||||||
| lymphoplasmacytic lymphoma | |||||||||||||||||||||||||||
| type 1 diabetes mellitus |
| Mouse Phenotypes | nervous system phenotype |
seizures |
increased susceptibility to dopaminergic neuron neurotoxicity |
abnormal microglial cell morphology |
microgliosis |
abnormal microglial cell physiology |
brain inflammation |
abnormal brain interneuron morphology |
abnormal brain white matter morphology |
abnormal substantia nigra pars compacta morphology |
abnormal Purkinje cell dendrite morphology |
decreased Purkinje cell number |
abnormal cerebellar granule cell morphology |
abnormal cerebellar molecular layer |
abnormal glial cell morphology |
abnormal CNS glial cell morphology |
abnormal astrocyte morphology |
astrocytosis |
gliosis |
abnormal neuron morphology |
abnormal axon morphology |
abnormal dendrite morphology |
decreased neuron number |
neurodegeneration |
spongiform encephalopathy |
abnormal nervous system physiology |
abnormal neuron physiology |
|
| Availability | Mouse Genotype | |||||||||||||||||||||||||||
| Il6tm1Kopf/Il6tm1Kopf | ||||||||||||||||||||||||||||
| Il6tm1Mur/Il6tm1Mur | ||||||||||||||||||||||||||||
| Tg(Gfap-Il6)G167Lms/Tg(Gfap-Il6)G167Lms | * | |||||||||||||||||||||||||||
| Tg(Gfap-Il6)G369Lms/Tg(Gfap-Il6)G369Lms | * | |||||||||||||||||||||||||||
| Tg(Gfap-Il6)G16Lms/0 Tg(Gfap-lacZ)1Lms/0 |
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| Tg(Gfap-Il6)G167Lms/0 | ||||||||||||||||||||||||||||
| Tg(Gfap-Il6)G369Lms/0 | ||||||||||||||||||||||||||||
| Il6tm1.1Jho/Il6tm1.1Jho Tg(GFAP-cre)8Gtm/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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